Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.
BackgroundFibrinogen is an essential hemostatic factor ROSE CASTILE SOAP and cardiovascular disease risk factor.Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wid